Treatment of the acute
ulcerative necrotizing gingivitis with OLEOZON¨.
Mart’nez M.,
MenŽndez S. and Castillo A. (Cuba)
The ulcerative necrotizing
gingivitis is a painful and destructive illness of the gingiva, characterized
by inflammation, redness, swelling and tendency to bleed. The aim of this study
is to evaluate the efficacy of OLEOZON¨ (sunflower ozonized oil) in the
treatment of ulcerative necrotizing gingivitis in an acute phase. A clinical
random trial, phase III, simple blind test, was carried out in 48 patients,
where OLEOZON¨ was compared with a
control group. The odontologist didnŐt know to what group belonged each
patient. Experimental group: 24 patients treated with OLEOZON¨, topically, 3 times
per day, during 7 days. Control group: patients treated, locally, with a
solution of sodium perborate, 3 times per day, during 7 days. The healing
criteria established were: disappearance of the lesions, pain, bleeding and
pseudomembrane. The evaluations were made at the 3rd and 7th days of beginning the
treatment. The results demonstrated that at the end of the treatment, in the
experimental group 75 % of patients cured in comparison with the control group
(29.2 %), with significant differences (p = 0.01) between both groups. Also, in
the experimental group the disappearance of symptoms was achieved more rapidly
in comparison with control group. No side effects were observed. It was
demonstrated that OLEOZON¨ is more effective in comparison with sodium perborate in
the treatment of patients with acute ulcerative necrotizing gingivitis, being
an appropriate therapeutic option for this disease.
Use of OLEOZON¨ in vaginal
monilia treatment.
El’as-Calles B., Savigne M.E. and Sayoux C. (Cuba)
Monilia or Candida
albicans
mycosis is a yeast vaginal infection. OLEOZON¨ (ozonized sunflower
oil) has a broad anti microbial spectrum, registered as antifungal product in
Cuba. In
vitro
studies, it has shown a great efficacy against yeasts. Taking into account its
germicidal properties, a group of 483 women (31 - 45 years old), suffering of
vaginal monilia, confirmed by clinical symptoms and microbiological tests, were
treated with OLEOZON¨. A cycle of daily vaginal embrocation, during 10 days,
was employed. If the treatment was not effective, a second cycle of treatment was
applied. The results demonstrated that 81.2 % of the patients showed no
evidence of clinical symptoms and 82.3 % of cases showed negative
microbiological tests after a first cycle treatment. The use of a second cycle,
showed no evidence of clinical symptoms in 84.3 % of cases and negative
microbiological tests in 87.2 % of patients.
Generalization of the use
of OLEOZON¨ in the
treatment of tinea pedis. Preliminary study
Falc—n L., Daniel R.D. and
MenŽndez S. (Cuba)
Tinea pedis is a frequently
occurring disease which produces different tissue lesions as desquamation,
maceration and pruritus. This clinical syndrome is often resistant to treatment
and frequently relapses occur. Ozonized sunflower oil, OLEOZON¨, has a remarkable
germicidal action. In a preceding paper, it has been demonstrated the efficacy
of OLEOZON¨ in patients with tinea
pedis, in a phase III clinical trial, using Nizoral as control group. The aim
of this study was to generalize the use of OLEOZON¨ in patients with tinea
pedis. Four hundred and forty three, in- and out- patients, from "Dr
Carlos J. Finlay" Military Hospital were treated topically (once a day)
with OLEOZON¨, during 6 weeks. The
results demonstrated that 381 patients (86 %) were healed and the most
effective results were found in scaled and macerated clinical forms. Slight
side effects were only seen in three patients.
OLEOZON¨: An effective
treatment in the management of pyodermitis.
Daniel R.D.,
Falcón; L., Moya S., Garbayo E. and MenŽndez S. (Cuba)
Pyoderma is an acute,
inflammatory, purulent disease. Taking into account the germicidal power of
ozonized sunflower oil (OLEOZON¨), we decided to study the efficacy of it in the treatment
of pyoderma and to compare it with Neobatin, as conventional drug. A sample of
1098 out-p atients, with clinical and bacteriological diagnosis of pyoderma,
was included in this study. The sample was divided at random into two groups:
OLEOZON¨ group and control
group, using Neobatin ointment treatment. It was indicated, in both groups, the
use of physiological saline compress, twenty minutes before topical application
of the specific treatment, in order to remove any crust. Treatments were
applied twice daily, during ten days. The results indicated that 90.1 % of the
OLEOZON¨ treated patients and
81.6 % of the Neobatin ointment treated patients were negative in the
bacteriological test, with statistical significant differences between groups.
We concluded that OLEOZON¨ is an effective treatment in the management of pyoderma.
Application of OLEOZON¨ in
vulvovaginitis.
Rubio R., El’-Calles B., Favier M., Castellanos G. and
Lescaille E. (Cuba)
The aim of this study is to
evaluate the efficacy of OLEOZON¨ in patients with vulvovaginitis. Three hundred fifty
women were treated with vaginal embrocations of OLEOZON¨, once a day, during 10
days. Microbiological vaginal exams were performed at the beginning and at the
end of the treatment. The women age group more affected was 25 - 34 years, and
all were workers. Candida albicans was the most frequent
microorganism present in this study. Leucorrhea was the symptom more frequent
and it disappeared since the 3rd day of treatment, as well as pruritus. The
evaluation criteria were disappearance of signs and simptoms and a negative
microbiological result. At the end of the treatment, 95 % of patients cured.
OLEOZON¨ can be a good
medication for the treatment of vulvovaginitis.
Evaluation of therapeutic
properties of OLEOZON¨ in the treatment of women
with Human Papilloma Virus (HPV) uteri cervix infection.
R’os M.A.,
Aguilar O., Torres A., Hern‡ndez M., MenŽndez S. and Amig— M. (Cuba)
HPV is associated with cervical cancer and preceding lesions. Cervical cancer is the second most common malignant tumor in the world, although its tendency is to occupy a first place in some geographic zones, such as Central and South America and the Caribbean region. In spite of several studies made worldwide to establish effective therapeutics against HPV infection, there isn't consensus about this. Now there are two different treatments for HPV infections. The first is based in lesion destruction by mean of chemicals or surgical methods, but they can't eliminate viral infection. The second one is based in viral elimination with antiviral agents. The ozonized sunflower oil (OLEOZON¨) has shown antiviral activity in the treatment of viral infections such as Herpes virus. Our main aim in this study was to evaluate the therapeutic efficacy of this product in HPV infected women. To develop this study we selected 12 women with NIC I, associated with HPV and condiloma acuminate lesions. OLEOZON¨ was applied daily, in the uteri cervix of each patient, during 20 days. Cytological, histological (in some cases) and colposcopic examination were made to each patient before and after the treatment. Two of the twelve left the treatment. From the rest, eight (80 %) women showed total clinical and cytological regression of lesions. Viral persistence was observed in two (20 %) patients. In some cases, total elimination of vaginal secretion, was observed after the treatment. Side effects due to the OLEOZON¨ were not observed in any case.